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KMID : 0350519950480010217
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Journal of Catholic Medical College
1995 Volume.48 No. 1 p.217 ~ p.226
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Prevention of Adhesion Syndrome after Extraocular Muscle Surgery in Rabbit
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Abstract
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Formation of adhesion secondary to extraocular muscle surgery may result in restricted ocular motility and thus lead to poor predictability and thus lead to poor predictability and prognosis.
Several high molecular weight polymers were tested as a barrier against adhesion between extraocular muscle and its surrounding tissue in a rabbit. We used 48 rabbits to investigate the efficacy of hyaluronic acid, methylcellulose, and Gelform as
compared to balanced salt solution as a control group in reducing the postoperative adhesion. Under general anesthesia, superior rectus muscle was detached and reattached to original insertion site after coating with barrier materials. Rabbits
were
killed and histologic examinations were done for degree of adhesion formation at 1, 2, 3, and 6 weeks after surgery.
@ES The results were as follows ;
@EN 1. In control group, the site of the most severe fibrosis was within muscle itself and the site of the least fibrosis was between muscle and sclera. But in experimental group, there was no differences in degree of fibrosis according to
operation
site.
2. In control group, the fibrosis progressively increased during the postoperative 6 weeks. In hyaluronic acid group and methylcellulose group, the fibrosis decreased from postoperative 1 week and the degree of decreased fibrosis was more
evident
in
methylcellulose group. In Gelform group, fibrosis decreased until postoperative 3 weeks and then increased at postoperative 6 weeks.
The above results suggest that high molecular weight polymers such as hyaluronic acid and methylcellulose are effective in prevention of adhesion syndrome after extraocular muscle surgery especially in methylcellulose group.
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